Korean hemorrhagic fever (KHF) was recognized in Korea for the first time in 1951 during Korean War among United Nations troops although similar disease to KHF had been reported as Haemorrhagic nephroso-nephritis in Russia, as Epidemic hemorrhagic fever (EHF) in China, as Nephropathia epidemica in Scandinavia and as Epidemic hemorrhagic fever in Eastern Europe and Japan.
In 1976, Lee and Lee discovered the etiologic agent of KHF in the lungs of Apodemus agrarius coreae and perfected a serologic test for the diagnosis of the disease.
In 1982, WHO unified these diseases similar to Korean hemorrhagic fever as Hemorrhagic fever with renal syndrome, and Hantaan and its related viruses were isolated also from house rats and colonized laboratory rats recently.
The results of multiplication and antibody formation of different strains of Hantaan virus in some species of laboratory animal are as following;
1. Various strains of virus were isolated from the lungs of wild rodent, Apodemus agrarius
t
coreae, and the blood of HFRS patients. When viral strains that were isolated from Apodemus mice and the patients were inoculated intramuscularly into Apodemus mice, we were able to demonstrate evidence of a great deal of viral proliferation in lung tissue. However, there was no evidence of viral proliferation in Apodemus mice when viral strains that were isolated from house rats were used.
2. When the virus that was isolated from urban rats was inoculated into SD rats, Wistar rats and Gunn´s rats, the best results of multiplication and antibody responses were demonstrated in Gunn´s rats.
3. With respect to production of IF antibodies, the virus which was isolated from blood of MFRS patients showed the most significant antigenicity when inoculated into Wistar rats.
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